Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts

20 Sept 2016

Abstract excerpt

Aging is a major risk factor in many forms of late-onset neurodegenerative disorders. The ability to recapitulate age-related characteristics of human neurons in culture will offer unprecedented opportunities to study the biological processes underlying neuronal aging. Here, we show that using a recently demonstrated microRNA-based cellular reprogramming approach, human fibroblasts from postnatal to near...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Pluripotent Stem Cells Research
Share to RNA Interference and Gene Delivery
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27644593
DOI: 10.7554/elife.18648

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblastsPMID 27644593Read ↗

Human iPSC-Derived Neurons as A Platform for Deciphering the Mechanisms behind Brain AgingSemantic proximity Read ↗

Lessons from inducible pluripotent stem cell models on neuronal senescence in aging and neurodegenerationSemantic proximity Read ↗

Human brain organoids record the passage of time over multiple years in cultureSemantic proximity Read ↗

An accelerated human in-vitro aging model mimics in-vivo aging and facilitates dynamic testing of anti-aging compoundsSemantic proximity Read ↗

Characterising the in vitro conversion of mouse fibroblasts into induced neurons using a CRISPR/Cas9 knock-out screenSemantic proximity Read ↗

Direct Reprogramming Rather than iPSC-Based Reprogramming Maintains Aging Hallmarks in Human Motor NeuronsSemantic proximity Read ↗

Age reprogramming: Innovations and ethical considerations for prolonged longevity (Review)Semantic proximity Read ↗

MiR-302a reprogrammed fibroblast-derived induced anti-aging neural stem cells improve cognition and prolong lifespan in Alzheimer's disease modelSemantic proximity Read ↗

Striatal neurons directly converted from Huntington's disease patient fibroblasts recapitulate age-associated disease phenotypes.Semantic proximity Read ↗

Protracted fate acquisition and epigenetic de-aging during induced neural stem cell conversion of human blood cellsSemantic proximity Read ↗

Epigenetic Reprogramming of Aging: Reversing the Clock for Regenerative MedicineSemantic proximity Read ↗

Unique transcriptional profiles of adult human immature neurons in healthy aging, Alzheimer’s disease, and cognitive resilienceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.