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REST suppression mediates neural conversion of adult human fibroblasts via microRNA‐dependent and ‐independent pathways

23 Jun 2017

Abstract excerpt

Direct conversion of human fibroblasts into mature and functional neurons, termed induced neurons (iNs), was achieved for the first time 6 years ago. This technology offers a promising shortcut for obtaining patient- and disease-specific neurons for disease modeling, drug screening, and other biomedical applications. However, fibroblasts from adult donors do not reprogram as easily as fetal donors, and no current...

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PMID: 28646119
DOI: 10.15252/emmm.201607471

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