Article

MiR-124 synergism with ELAVL3 enhances target gene expression to promote neuronal maturity

2020-03-25

Abstract excerpt

<h4>Summary</h4> Neuron-enriched microRNAs (miRNAs), miR-9/9* and miR-124 (miR-9/9*-124), direct cell fate switching of human fibroblasts to neurons when ectopically expressed by repressing anti-neurogenic genes. How these miRNAs function after the onset of the transcriptome switch to a neuronal fate remains unclear. Here, we identified direct targets of miRNAs by Argonaute (AGO) HITS-CLIP as reprogramming cells...

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Literature Corpus work: e66ab9c6-5696-56ab-846f-6579cfdf914f
DOI: 10.1101/2020.03.25.006635

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