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Differentiation hierarchy in adult B cell acute lymphoblastic leukemia at clonal resolution

2025-09-16

Abstract excerpt

While a differentiation hierarchy with leukemia-initiating stem cells (LICs) at the apex is well documented for acute myeloid leukemia, the existence of LICs and their trajectories in B cell acute lymphoblastic leukemia (B-ALL) are debated. B-ALL is a malignant disease displaying considerable phenotypical and functional heterogeneity, yet the underlying cellular organization remains largely elusive. This study aim...

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Literature Corpus work
2d272c31-3799-5458-a2ca-6aeb25694f91
DOI
10.1101/2025.09.10.674954
Open publication

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Differentiation hierarchy in adult B cell acute lymphoblastic leukemia at clonal resolutionDOI 10.1101/2025.09.10.674954
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