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Identification of leukemia-enriched signature through the development of a comprehensive pediatric single-cell atlas

2 May 2025

Abstract excerpt

Single-cell transcriptome profiling enables unparalleled characterization of the heterogeneous microenvironment of pediatric leukemias. To facilitate comparative analyses and generate pediatric leukemia signatures, we collect, process, and annotate single-cell data comprising over 540,000 cells from 159 different pediatric acute leukemia (myeloid, lymphoid, mixed phenotype lineages) and healthy bone marrow (BM)...

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Cytomegalovirus and herpesvirus research
Immune cells in cancer
Single-cell and spatial transcriptomics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40316535
DOI: 10.1038/s41467-025-59362-5

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