Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of leukemia-enriched signature through the development of a comprehensive pediatric single-cell atlas

2 May 2025

Abstract excerpt

Single-cell transcriptome profiling enables unparalleled characterization of the heterogeneous microenvironment of pediatric leukemias. To facilitate comparative analyses and generate pediatric leukemia signatures, we collect, process, and annotate single-cell data comprising over 540,000 cells from 159 different pediatric acute leukemia (myeloid, lymphoid, mixed phenotype lineages) and healthy bone marrow (BM)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to Immune cells in cancer
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40316535
DOI: 10.1038/s41467-025-59362-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of leukemia-enriched signature through the development of a comprehensive pediatric single-cell atlasPMID 40316535Read ↗

Progress and Prospects in Pediatric Leukemia.Semantic proximity Read ↗

Single-cell multi-omics reveals elevated plasticity and stem-cell-like blasts relevant to the poor prognosis of <i>KMT2A</i> -rearranged leukemiaSemantic proximity Read ↗

A comprehensive bulk and single-cell transcriptional atlas of pediatric leukemiasSemantic proximity Read ↗

Single-cell analysis of acute lymphoblastic and lineage-ambiguous leukemia: approaches and molecular insightsSemantic proximity Read ↗

Decoding leukemia at the single-cell level: clonal architecture, classification, microenvironment, and drug resistanceSemantic proximity Read ↗

A longitudinal single-cell atlas of treatment response in pediatric AMLSemantic proximity Read ↗

Single-cell analysis of pediatric acute myeloid leukemia samples uncovers treatment-resistant stem and mast cellsSemantic proximity Read ↗

Mining single-cell transcriptomic data reveals distinct T-cell population in pediatric B-ALL and AML at diagnosisSemantic proximity Read ↗

Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell–like blasts in KMT2A -rearranged leukemiaSemantic proximity Read ↗

Single-cell Transcriptional Atlas of Human Hematopoiesis Reveals Genetic and Hierarchy-Based Determinants of Aberrant AML DifferentiationSemantic proximity Read ↗

Integrated decoding hematopoiesis and leukemogenesis using single-cell sequencing and its medical implicationSemantic proximity Read ↗

Integrated decoding hematopoiesis and leukemogenesis at single-cell resolution and its clinical implicationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.