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Novel mouse model of cerebral microbleeds created by Crispr/Cas9-mediated <i>Col4a1</i> deletion in adult brain microvessels

2025-06-25

Abstract excerpt

Cerebral small vessel disease is a leading cause of cognitive decline and stroke in the elderly, with cerebral microbleeds (CMBs) as one of the key imaging biomarkers. Our understanding of its pathophysiology remains limited due to the lack of appropriate animal models. We report a novel mouse CMB model created by disrupting collagen IV, a core component of the vascular basement membrane (BM), specifically within...

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Identifiers and source

Literature Corpus work
a043b722-c854-533a-8849-2fdac704cc0e
DOI
10.1101/2025.06.22.660900
Open publication

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Novel mouse model of cerebral microbleeds created by Crispr/Cas9-mediated <i>Col4a1</i> deletion in adult brain microvesselsDOI 10.1101/2025.06.22.660900
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