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Article

Loss of col4a1 in zebrafish recapitulates the cerebrovascular phenotypes associated with monogenic cerebral small vessel disease.

Matrix biology : journal of the International Society for Matrix Biology - 1 Nov 2025

Flatman Daisy, Naylor Richard W, Crilly Siobhan, Carter Isabel, Mironov Aleksandr, Pinteaux Emmanuel, Allan Stuart M, Lennon Rachel, Kasher Paul R

Abstract excerpt

Cerebral small vessel disease (cSVD) is a major cause of vascular dementia and stroke. Our understanding of cSVD pathophysiology is incomplete and our ability to treat patients is limited. Pathogenic variants in type IV collagen alpha 1 (COL4A1) cause a monogenic form of cSVD with variable age of onset, via disturbance of cerebrovascular basement membranes. Zebrafish larvae are a powerful model organism for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40846110
DOI: 10.1016/j.matbio.2025.08.005

Genes

COL4A1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Loss of col4a1 in zebrafish recapitulates the cerebrovascular phenotypes associated with monogenic cerebral small vessel disease.PMID 40846110Read ↗

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