Article
Role of COL4A1 in small-vessel disease and hemorrhagic stroke.
The New England journal of medicine - 6 Apr 2006
Gould Douglas B, Phalan F Campbell, van Mil Saskia E, Sundberg John P, Vahedi Katayoun, Massin Pascale, Bousser Marie Germaine, Heutink Peter, Miner Jeffrey H, Tournier-Lasserve Elisabeth, John Simon W M
Abstract excerpt
Small-vessel diseases of the brain underlie 20 to 30 percent of ischemic strokes and a larger proportion of intracerebral hemorrhages. In this report, we show that a mutation in the mouse Col4a1 gene, encoding procollagen type IV alpha1, predisposes both newborn and adult mice to intracerebral hemorrhage. Surgical delivery of mutant mice alleviated birth-associated trauma and hemorrhage. We identified a COL4A1...
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