Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Elevated TGFβ signaling contributes to cerebral small vessel disease in mouse models of Gould syndrome.

Matrix biology : journal of the International Society for Matrix Biology - 1 Jan 2023

Branyan Kayla, Labelle-Dumais Cassandre, Wang Xiaowei, Hayashi Genki, Lee Bryson, Peltz Zoe, Gorman Seán, Li Bo Qiao, Mao Mao, Gould Douglas B

Abstract excerpt

Cerebral small vessel disease (CSVD) is a leading cause of stroke and vascular cognitive impairment and dementia. Studying monogenic CSVD can reveal pathways that are dysregulated in common sporadic forms of the disease and may represent therapeutic targets. Mutations in collagen type IV alpha 1 (COL4A1) and alpha 2 (COL4A2) cause highly penetrant CSVD as part of a multisystem disorder referred to as Gould...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basement Membrane
Share to Cerebral Hemorrhage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cerebral Small Vessel Diseases

Share to Collagen Type IV

Share to Disease Models, Animal

Share to Mutation

Share to Transforming Growth Factor beta

Source

Open in PubMed Open full text

Identifiers

PMID: 36435425
DOI: 10.1016/j.matbio.2022.11.007
PMCID: PMC10393528

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Elevated TGFβ signaling contributes to cerebral small vessel disease in mouse models of Gould syndrome.PMID 36435425Read ↗

Skeletal pathology in mouse models of Gould syndrome is partially alleviated by genetically reducing TGFβ signaling.Semantic proximity Read ↗

Loss of col4a1 in zebrafish recapitulates the cerebrovascular phenotypes associated with monogenic cerebral small vessel disease.Semantic proximity Read ↗

Molecular and Genetic Analyses of Collagen Type IV Mutant Mouse Models of Spontaneous Intracerebral Hemorrhage Identify Mechanisms for Stroke Prevention.Semantic proximity Read ↗

Perturbations of the cerebrovascular matrisome: A convergent mechanism in small vessel disease of the brain?Semantic proximity Read ↗

Deregulated TGF-β/BMP Signaling in Vascular Malformations.Semantic proximity Read ↗

Biology of vascular malformations of the brain.Semantic proximity Read ↗

Cerebral small vessel disease due to <i>Col4a1</i> mutations include cognitive impairment and white matter defects that can be modulated by targeting protein foldingSemantic proximity Read ↗

Cerebrovascular p16INK4A expression induces cerebral small vessel disease-related phenotypes.Semantic proximity Read ↗

Novel mouse model of cerebral microbleeds created by Crispr/Cas9-mediated <i>Col4a1</i> deletion in adult brain microvesselsSemantic proximity Read ↗

HTRA1 deficiency in <i>COL4A1</i> mutant hiPSC-derived astrocytes: a convergent mechanism of cerebral small vessel diseaseSemantic proximity Read ↗

A novel human iPSC model of COL4A1/A2 small vessel disease unveils a key pathogenic role of matrix metalloproteinasesSemantic proximity Read ↗

A novel human iPSC model of COL4A1/A2 small vessel disease unveils a key pathogenic role of matrix metalloproteinases in extracellular matrix abnormalitiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.