Article

Increased Collagen I/ Collagen III Ratio Is Associated with Hemorrhage in Brain Arteriovenous Malformations in Human and Mouse

2023-12-06

Abstract excerpt

<h4>Background: </h4> Increase of collagen I (COL I)/COL III ratio enhances vessel wall stiffness and renders vessels less resistant to blood flow and pressure changes. We hypothesized that COL I/COL III ratio is increased in the brain arteriovenous malformations (bAVMs), which is associated with bAVM hemorrhage. <h4>Method:</h4> Surgically resected human bAVM samples and mouse bAVMs induced in three transgenic mo...

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Literature Corpus work: 2cb69a22-a6c3-5f0f-9cb0-da78f7e84eda
DOI: 10.20944/preprints202312.0389.v1

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