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HTRA1 deficiency in <i>COL4A1</i> mutant hiPSC-derived astrocytes: a convergent mechanism of cerebral small vessel disease

2026-05-13

Abstract excerpt

Cerebral small vessel disease (cSVD) is a major contributor to stroke and cognitive decline, ultimately leading to vascular dementia (VaD). Genetic factors play a key role in disease susceptibility and progression, and variants in COL4A1 cause one of the most common forms of genetic cSVD. COL4A1 encodes the α1 chain of collagen type IV which is the major structural component of the basement membrane, a specialis...

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Literature Corpus work
804d661f-a873-542b-be9b-528d272c81e4
DOI
10.64898/2026.05.12.724691
Open publication

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HTRA1 deficiency in <i>COL4A1</i> mutant hiPSC-derived astrocytes: a convergent mechanism of cerebral small vessel diseaseDOI 10.64898/2026.05.12.724691
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