Article

Establishment of a novel patient hiPSC-derived in vitro blood-brain barrier model of collagen IV small vessel disease

2020-01-01

Abstract excerpt

Cerebral small vessel disease (SVD) is a prevalent cause of stroke (25-30%) and dementia (45%). Despite its frequency, little is known about the cause and disease progression of SVD. Matrisome alteration leading to blood-brain barrier (BBB) dysfunction is thought to play a role. Sporadic cases are exacerbated by age and vascular risk factors, predominantly affecting the elderly. However, mutations in Collagen IV α...

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Literature Corpus work: 068246a5-25d7-5850-8b52-9b0fc21a3696
DOI: 10.17863/cam.65766

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