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Article

Severity of arterial defects in the retina correlates with the burden of intracerebral haemorrhage in COL4A1-related stroke.

The Journal of pathology - 1 Apr 2018

Ratelade Julien, Mezouar Nicolas, Domenga-Denier Valérie, Rochey Ambre, Plaisier Emmanuelle, Joutel Anne

Abstract excerpt

Mutations in the α1 (COL4A1) or α2 (COL4A2) chains of collagen type IV, a major component of the vascular basement membrane, cause intracerebral haemorrhages with variable expressivity and reduced penetrance by mechanisms that remain poorly understood. Here we sought to investigate the cellular mechanisms of COL4A1-related intracerebral haemorrhage and identify a marker for haemorrhage risk stratification. A...

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PMID: 29266233
DOI: 10.1002/path.5023

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Severity of arterial defects in the retina correlates with the burden of intracerebral haemorrhage in COL4A1-related stroke.PMID 29266233Read ↗

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