Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reduced expression of integrin alphavbeta8 is associated with brain arteriovenous malformation pathogenesis.

The American journal of pathology - 1 Feb 2010

Su Hua, Kim Helen, Pawlikowska Ludmila, Kitamura Hideya, Shen Fanxia, Cambier Stephanie, Markovics Jennifer, Lawton Michael T, Sidney Stephen, Bollen Andrew W, Kwok Pui-Yan, Reichardt Louis, Young William L, Yang Guo-Yuan, Nishimura Stephen L

Abstract excerpt

Brain arteriovenous malformations (BAVMs) are a rare but potentially devastating hemorrhagic disease. Transforming growth factor-beta signaling is required for proper vessel development, and defective transforming growth factor-beta superfamily signaling has been implicated in BAVM pathogenesis. We hypothesized that expression of the transforming growth factor-beta activating integrin, alphavbeta8, is reduced in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Down-Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Integrins

Share to Intracranial Arteriovenous Malformations

Share to Linkage Disequilibrium

Share to Mice, Transgenic

Share to Neovascularization, Physiologic

Share to Transforming Growth Factor beta

Source

Open in PubMed Open full text

Identifiers

PMID: 20019187
DOI: 10.2353/ajpath.2010.090453
PMCID: PMC2808104

Genes

ITGB8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reduced expression of integrin alphavbeta8 is associated with brain arteriovenous malformation pathogenesis.PMID 20019187Read ↗

Platelet-derived growth factor receptor β F7 mutations result in and exacerbate the severity of vascular dysplasia in the brain arteriovenous malformation through enhancing angiogenesis.Semantic proximity Read ↗

Advances in the Genetics and Molecular Biology of Brain Arteriovenous Malformations.Semantic proximity Read ↗

Understanding the pathogenesis of brain arteriovenous malformation: genetic variations, epigenetics, signaling pathways, and immune inflammation.Semantic proximity Read ↗

Somatic BrafV600E mutation in the cerebral endothelium induces brain arteriovenous malformations.Semantic proximity Read ↗

Arteriovenous malformation in the adult mouse brain resembling the human disease.Semantic proximity Read ↗

Review of treatment and therapeutic targets in brain arteriovenous malformation.Semantic proximity Read ↗

Beta8 integrin regulates neurogenesis and neurovascular homeostasis in the adult brain.Semantic proximity Read ↗

Pathogenesis of Brain Arteriovenous MalformationsSemantic proximity Read ↗

The astrocyte-expressed integrin αvβ8 governs blood vessel sprouting in the developing retina.Semantic proximity Read ↗

RNA-Sequencing Highlights Inflammation and Impaired Integrity of the Vascular Wall in Brain Arteriovenous MalformationsSemantic proximity Read ↗

Recent Advances in Basic Research for Brain Arteriovenous Malformation.Semantic proximity Read ↗

Genome-wide association study of sporadic brain arteriovenous malformations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.