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Article

Somatic BrafV600E mutation in the cerebral endothelium induces brain arteriovenous malformations.

Angiogenesis - 1 Aug 2024

Tu Tianqi, Yu Jiaxing, Jiang Chendan, Zhang Shikun, Li Jingwei, Ren Jian, Zhang Shiju, Zhou Yuan, Cui Ziwei, Lu Haohan, Meng Xiaosheng, Wang Zhanjing, Xing Dong, Zhang Hongqi, Hong Tao

Abstract excerpt

Current treatments of brain arteriovenous malformation (BAVM) are associated with considerable risks and at times incomplete efficacy. Therefore, a clinically consistent animal model of BAVM is urgently needed to investigate its underlying biological mechanisms and develop innovative treatment strategies. Notably, existing mouse models have limited utility due to heterogenous and untypical phenotypes of AVM...

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Identifiers

PMID: 38700584
DOI: 10.1007/s10456-024-09918-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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