Article
Hyper-Acetylation of Histone H3K56 Limits Break-Induced Replication by Inhibiting Extensive Repair Synthesis.
PLoS genetics - 1 Feb 2015
Che Jun, Smith Stephanie, Kim Yoo Jung, Shim Eun Yong, Myung Kyungjae, Lee Sang Eun
Abstract excerpt
Break-induced replication (BIR) has been implicated in restoring eroded telomeres and collapsed replication forks via single-ended invasion and extensive DNA synthesis on the recipient chromosome. Unlike other recombination subtypes, DNA synthesis in BIR likely relies heavily on mechanisms enabling efficient fork progression such as chromatin modification. Herein we report that deletion of HST3 and HST4, two...
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