ATR-dependent pathways control hEXO1 stability in response to stalled forks.

doi:10.1093/nar/gkm1052

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Article

ATR-dependent pathways control hEXO1 stability in response to stalled forks.

Nucleic acids research - 1 Feb 2008

El-Shemerly Mahmoud, Hess Daniel, Pyakurel Aswin K, Moselhy Said, Ferrari Stefano

Abstract excerpt

Nucleases play important roles in DNA synthesis, recombination and repair. We have previously shown that human exonuclease 1 (hEXO1) is phosphorylated in response to agents stalling DNA replication and that hEXO1 consequently undergoes ubiquitination and degradation in a proteasome-dependent manner. In the present study, we have addressed the identity of the pathway transducing stalled-replication signals to...

Topics

Animals
Antibodies, Phospho-Specific
Ataxia Telangiectasia Mutated Proteins
Cell Cycle Proteins
Cell Line
DNA Repair Enzymes
DNA Replication
Enzyme Stability
Exodeoxyribonucleases
HeLa Cells
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hydroxyurea

Mice

Mutation

Phosphorylation

Phosphoserine

Protein Serine-Threonine Kinases

Signal Transduction

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PMID: 18048416
DOI: 10.1093/nar/gkm1052
PMCID: PMC2241874

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