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Article

ATR-dependent pathways control hEXO1 stability in response to stalled forks.

Nucleic acids research - 1 Feb 2008

El-Shemerly Mahmoud, Hess Daniel, Pyakurel Aswin K, Moselhy Said, Ferrari Stefano

Abstract excerpt

Nucleases play important roles in DNA synthesis, recombination and repair. We have previously shown that human exonuclease 1 (hEXO1) is phosphorylated in response to agents stalling DNA replication and that hEXO1 consequently undergoes ubiquitination and degradation in a proteasome-dependent manner. In the present study, we have addressed the identity of the pathway transducing stalled-replication signals to...

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Identifiers

PMID: 18048416
DOI: 10.1093/nar/gkm1052
PMCID: PMC2241874

Genes

ATR
ATM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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