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Article

Strand separation establishes a sustained lock at the Tus-Ter replication fork barrier.

Nature chemical biology - 1 Aug 2015

Berghuis Bojk A, Dulin David, Xu Zhi-Qiang, van Laar Theo, Cross Bronwen, Janissen Richard, Jergic Slobodan, Dixon Nicholas E, Depken Martin, Dekker Nynke H

Abstract excerpt

The bidirectional replication of a circular chromosome by many bacteria necessitates proper termination to avoid the head-on collision of the opposing replisomes. In Escherichia coli, replisome progression beyond the termination site is prevented by Tus proteins bound to asymmetric Ter sites. Structural evidence indicates that strand separation on the blocking (nonpermissive) side of Tus-Ter triggers roadblock...

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Identifiers

PMID: 26147356
DOI: 10.1038/nchembio.1857

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Strand separation establishes a sustained lock at the Tus-Ter replication fork barrier.PMID 26147356Read ↗

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