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Article

DNA-PKcs is required to maintain stability of Chk1 and Claspin for optimal replication stress response.

Nucleic acids research - 1 Apr 2014

Lin Yu-Fen, Shih Hung-Ying, Shang Zengfu, Matsunaga Shinji, Chen Benjamin Pc

Abstract excerpt

The ataxia telangiectasia mutated and Rad3-related (ATR)-checkpoint kinase 1 (Chk1) axis is the major signaling pathway activated in response to replication stress and is essential for the intra-S checkpoint. ATR phosphorylates and activates a number of molecules to coordinate cell cycle progression. Chk1 is the major effector downstream from ATR and plays a critical role in intra-S checkpoint on replication...

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Source

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Identifiers

PMID: 24500207
DOI: 10.1093/nar/gku116
PMCID: PMC3985680

Genes

ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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