Article

Subtype-Specific SASP Dynamics Predict Mesenchymal Transition in Recurrent Glioblastoma

2026-01-16

Abstract excerpt

<h4>Background</h4> Therapy-induced senescence is hypothesized to promote glioblastoma recurrence through senescence-associated secretory phenotype (SASP) factors, yet no longitudinal study has tracked SASP dynamics across matched primary-recurrent pairs. We used the GLASS consortium to characterize ΔSASP trajectories and their clinical implications. <h4>Methods</h4> We analyzed 167 matched primary-recurrent GBM...

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Literature Corpus work: a02bdce3-db3a-5e99-835b-82faa79ad2bc
DOI: 10.64898/2026.01.15.699753

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