Article

Treatment Resistant Persister Cells Exploit Macrophage Lipid Metabolism to Sustain Glioblastoma Growth

2025-06-10

Abstract excerpt

<h4>SUMMARY</h4> Glioblastoma (GBM) displays pronounced intratumoral heterogeneity, posing significant challenges to understanding its biology and developing effective treatments. Using spatial multi-omics, in vivo functional assays, and systems-level analysis, we delineate the diverse metabolic and immune architecture of GBM. We identify a lipid-dependent lineage of treatment-resistant persister cells (TRPCs) t...

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Literature Corpus work: e7d1bfa6-5568-5bda-a948-b9ef52e0ae09
DOI: 10.1101/2025.06.07.658345

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