Article

Subclonal evolution and expansion of spatially distinct THY1-positive cells is associated with recurrence in glioblastoma

2021-09-10

Abstract excerpt

<h4>Purpose</h4> Glioblastoma (GBM) is a lethal disease characterized by inevitable recurrence. Here we investigate the molecular pathways mediating resistance, with the goal of identifying therapeutic opportunities to target this tumor. <h4>Experimental Design</h4> We developed a longitudinal in vivo recurrence model utilizing patient-derived explants to produce paired specimens (pre- and post-recurrence) foll...

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Literature Corpus work: 325e3704-7459-5ae8-a5cb-8aeb452bdaf9
DOI: 10.1101/2021.09.10.459454

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