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Article

A single-cell atlas of glioblastoma evolution under therapy reveals cell-intrinsic and cell-extrinsic therapeutic targets.

Nature cancer - 1 Dec 2022

Wang Lin, Jung Jangham, Babikir Husam, Shamardani Karin, Jain Saket, Feng Xi, Gupta Nalin, Rosi Susanna, Chang Susan, Raleigh David, Solomon David, Phillips Joanna J, Diaz Aaron A

Abstract excerpt

Recent longitudinal studies of glioblastoma (GBM) have demonstrated a lack of apparent selection pressure for specific DNA mutations in recurrent disease. Single-cell lineage tracing has shown that GBM cells possess a high degree of plasticity. Together this suggests that phenotype switching, as opposed to genetic evolution, may be the escape mechanism that explains the failure of precision therapies to date. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36539501
DOI: 10.1038/s43018-022-00475-x
PMCID: PMC9767870

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