Decoding key cell sub-populations and molecular alterations in glioblastoma at recurrence by single-cell analysis

Abstract excerpt

Glioblastoma (GBM) is the most frequent malignant brain tumor, the relapse of which is unavoidable following standard treatment. However, the effective treatment for recurrent GBM is lacking, necessitating the understanding of key mechanisms driving tumor recurrence and the identification of new targets for intervention. Here, we integrated single-cell RNA-sequencing data spanning 36 patient-matched primary and...

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• Glioma Diagnosis and Treatment
• Neuroinflammation and Neurodegeneration Mechanisms
• Single-cell and spatial transcriptomics