Article

Integrated longitudinal analysis of glioblastomas with long-term relapse interval revealed upregulation of the Tumor Growth Factor β signaling pathway in the recurrent tumor

2022-02-25

Abstract excerpt

<h4>Background: </h4> . Glioblastoma (GBM) is the most aggressive primary brain tumor and represents a particular challenge of therapeutic intervention. <h4>Methods: </h4> . In a single-center retrospective study of matched pairs of initial and post-therapeutic GBM cases with a recurrence period greater than one year, we performed whole exome sequencing combined with mRNA and microRNA expression profiling to ident...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8c696418-e1a1-54f4-833e-77d0ca490c24
DOI: 10.21203/rs.3.rs-1350734/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrated longitudinal analysis of glioblastomas with long-term relapse interval revealed upregulation of the Tumor Growth Factor β signaling pathway in the recurrent tumorDOI 10.21203/rs.3.rs-1350734/v1Read

Integrated longitudinal analysis of adult grade 4 diffuse gliomas with long-term relapse interval revealed upregulation of TGF-β signaling in recurrent tumorsSemantic proximity Read

Clonal evolution of glioblastoma under therapy.Semantic proximity Read

Subclonal evolution and expansion of spatially distinct THY1-positive cells is associated with recurrence in glioblastomaSemantic proximity Read

Decoding key cell sub-populations and molecular alterations in glioblastoma at recurrence by single-cell analysisSemantic proximity Read

Subclonal evolution and expansion of spatially distinct THY1-positive cells is associated with recurrence in glioblastomaSemantic proximity Read

Temporospatial genomic profiling in glioblastoma identifies commonly altered core pathways underlying tumor progressionSemantic proximity Read

Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution.Semantic proximity Read

A longer time to relapse is associated with a larger increase in differences between paired primary and recurrent IDH wild-type glioblastomas at both the transcriptomic and genomic levels.Semantic proximity Read

Mutational Analysis Reveals the Origin and Therapy-Driven Evolution of Recurrent GliomaSemantic proximity Read

Overview of Transforming Growth Factor β Superfamily Involvement in Glioblastoma Initiation and ProgressionSemantic proximity Read

Comprehensive portrait of recurrent glioblastoma multiforme in molecular and clinical characteristics.Semantic proximity Read

Whole exome sequencing reveals the genetic heterogeneity and evolutionary history of primary gliomas and matched recurrencesSemantic proximity Read