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Article

Temporal change of DNA methylation subclasses between matched newly diagnosed and recurrent glioblastoma

20 Jan 2024

Abstract excerpt

The longitudinal transition of phenotypes is pivotal in glioblastoma treatment resistance and DNA methylation emerged as an important tool for classifying glioblastoma phenotypes. We aimed to characterize DNA methylation subclass heterogeneity during progression and assess its clinical impact. Matched tissues from 47 glioblastoma patients were subjected to DNA methylation profiling, including CpG-site...

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PMID: 38244080
DOI: 10.1007/s00401-023-02677-8

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