Article
Minimal functional driver gene heterogeneity among untreated metastases.
Science (New York, N.Y.) - 7 Sept 2018
Reiter Johannes G, Makohon-Moore Alvin P, Gerold Jeffrey M, Heyde Alexander, Attiyeh Marc A, Kohutek Zachary A, Tokheim Collin J, Brown Alexia, DeBlasio Rayne M, Niyazov Juliana, Zucker Amanda, Karchin Rachel, Kinzler Kenneth W, Iacobuzio-Donahue Christine A, Vogelstein Bert, Nowak Martin A
Abstract excerpt
Metastases are responsible for the majority of cancer-related deaths. Although genomic heterogeneity within primary tumors is associated with relapse, heterogeneity among treatment-naïve metastases has not been comprehensively assessed. We analyzed sequencing data for 76 untreated metastases from 20 patients and inferred cancer phylogenies for breast, colorectal, endometrial, gastric, lung, melanoma, pancreatic,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.