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Article

Mutational profiles of breast cancer metastases from a rapid autopsy series reveal multiple evolutionary trajectories.

JCI insight - 21 Dec 2017

Avigdor Bracha Erlanger, Cimino-Mathews Ashley, DeMarzo Angelo M, Hicks Jessica L, Shin James, Sukumar Saraswati, Fetting John, Argani Pedram, Park Ben H, Wheelan Sarah J

Abstract excerpt

Heterogeneity within and among tumors in a metastatic cancer patient is a well-established phenomenon that may confound treatment and accurate prognosis. Here, we used whole-exome sequencing to survey metastatic breast cancer tumors from 5 patients in a rapid autopsy program to construct the origin and genetic development of metastases. Metastases were obtained from 5 breast cancer patients using a rapid autopsy...

Topics

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Autopsy
DNA Copy Number Variations
DNA, Neoplasm
Exome Sequencing
Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Neoplasm

Loss of Heterozygosity

Neoplasm Metastasis

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Open in PubMed Open full text

Identifiers

PMID: 29263308
DOI: 10.1172/jci.insight.96896
PMCID: PMC5752302

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