Article

Leucine-rich repeat in polycystin-1 suppresses cystogenesis in a zebrafish (Danio rerio) model of autosomal dominant polycystic kidney disease

2024-01-29

Abstract excerpt

Mutations of PKD1 coding for polycystin-1 (PC1) account for most of the autosomal dominant polycystic kidney disease (ADPKD). The extracellular region of PC1 contains many evolutionarily conserved domains for ligand interactions. Among these is the leucine-rich repeats (LRR) in the far N-terminus of PC1. Using zebrafish (Danio rerio) as an in vivo model system, we explored the role of LRR in the function of PC1. Z...

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Literature Corpus work: a024c623-8253-5da1-b9e5-7e1e17922265
DOI: 10.20944/preprints202401.1959.v1

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