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Article

Polycystin-1 regulates ARHGAP35-dependent centrosomal RhoA activation and ROCK signaling.

JCI insight - 20 Aug 2020

Streets Andrew J, Prosseda Philipp P, Ong Albert Cm

Abstract excerpt

Mutations in PKD1 (encoding for polycystin-1 [PC1]) are found in 80%-85% of patients with autosomal dominant polycystic kidney disease (ADPKD). We tested the hypothesis that changes in actin dynamics result from PKD1 mutations through dysregulation of compartmentalized centrosomal RhoA signaling mediated by specific RhoGAP (ARHGAP) proteins resulting in the complex cellular cystic phenotype. Initial studies...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polycystic Kidney, Autosomal Dominant

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Source

Open in PubMed Open full text

Identifiers

PMID: 32663194
DOI: 10.1172/jci.insight.135385
PMCID: PMC7455122

Genes

PKD1
ARHGAP35
ARHGAP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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