Article
Pioglitazone improves the phenotype and molecular defects of a targeted Pkd1 mutant.
Human molecular genetics - 15 Jul 2002
Muto Satoru, Aiba Atsu, Saito Yuichirou, Nakao Kazuki, Nakamura Kenji, Tomita Kyoichi, Kitamura Tadaichi, Kurabayashi Masahiko, Nagai Ryozo, Higashihara Eiji, Harris Peter C, Katsuki Motoya, Horie Shigeo
Abstract excerpt
Mutations of either PKD1 or PKD2 are associated with autosomal dominant polycystic kidney disease (ADPKD). The molecular function of the gene product of PKD1, polycystin-1, in vitro has been elucidated recently, but the molecular pathological consequences of the loss of polycystin-1 in vivo have remained unclear. We have generated a mouse with a targeted deletion of exons 2-6 of Pkd1 to study the molecular...
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