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Article

The polycystin-1 C-terminal fragment triggers branching morphogenesis and migration of tubular kidney epithelial cells.

The Journal of clinical investigation - 1 Feb 2002

Nickel Christian, Benzing Thomas, Sellin Lorenz, Gerke Peter, Karihaloo Anil, Liu Zhen-Xiang, Cantley Lloyd G, Walz Gerd

Abstract excerpt

Mutations of either PKD1 or PKD2 cause autosomal dominant polycystic kidney disease, a syndrome characterized by extensive formation of renal cysts and progressive renal failure. Homozygous deletion of Pkd1 or Pkd2, the genes encoding polycystin-1 and polycystin-2, disrupt normal renal tubular differentiation in mice but do not affect the early steps of renal development. Here, we show that expression of the...

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Source

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Identifiers

PMID: 11854320
DOI: 10.1172/JCI12867
PMCID: PMC150870

Genes

HGF
PKD1
PKD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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