Article

BICC1 Interacts with PKD1 and PKD2 to Drive Cystogenesis in ADPKD

2024-08-27

Abstract excerpt

<h4>ABSTRACT</h4> Autosomal dominant polycystic kidney disease (ADPKD) is primarily of adult-onset and caused by pathogenic variants in PKD1 or PKD2 . Yet, disease expression is highly variable and includes very early-onset PKD presentations in utero or infancy. In animal models, the RNA-binding molecule Bicc1 has been shown to play a crucial role in the pathogenesis of PKD. To study the interaction between BI...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3d2899d4-0b55-532d-96a3-b9beccc1964c
DOI: 10.1101/2024.08.27.608867

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

BICC1 Interacts with PKD1 and PKD2 to Drive Cystogenesis in ADPKDDOI 10.1101/2024.08.27.608867Read

Autosomal dominant polycystic kidney disease: clues to pathogenesis.Semantic proximity Read

Molecular pathogenesis of ADPKD: the polycystin complex gets complex.Semantic proximity Read

Prenatal diagnosis of polycystic kidney caused by biallelic hypomorphic variants in the PKD1 gene.Semantic proximity Read

Generation of Mice Harboring Bicc1 Conditional Null Alleles.Semantic proximity Read

The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity.Semantic proximity Read

Molecular genetics of polycystic kidney disease.Semantic proximity Read

The Role of the Co-Chaperone DNAJB11 in Polycystic Kidney Disease: Molecular Mechanisms and Cellular Origin of Cyst FormationSemantic proximity Read

A missense mutation in PKD1 attenuates the severity of renal disease.Semantic proximity Read

Molecular and cellular pathogenesis of autosomal dominant polycystic kidney disease.Semantic proximity Read

A polycystin-centric view of cyst formation and disease: the polycystins revisited.Semantic proximity Read

Autosomal dominant polycystic kidney disease (ADPKD, MIM 173900, PKD1 and PKD2 genes, protein products known as polycystin-1 and polycystin-2).Semantic proximity Read

Heterozygous truncating variants in BICC1 are a novel cause of autosomal-dominant tubulointerstitial kidney diseaseSemantic proximity Read