Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Peptides from the PKD repeats of polycystin, the PKD1 gene product, modulate pattern formation in the developing kidney.

Developmental genetics - 1 Jan 1999

van Adelsberg J

Abstract excerpt

Mutations in the PKD1 gene cause the majority of cases of autosomal dominant polycystic kidney disease. The PKD1 gene codes for a protein of unknown function, polycystin-1, that is predicted to be a receptor. Its large extracellular domain contains 16 copies of novel motif, the PKD repeat, that is likely to be a ligand binding domain based on its similarity to immunoglobulin domains. These observations suggested...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Patterning
Share to Fishes
Share to Microscopy, Confocal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Organ Culture Techniques

Share to Peptide Fragments

Share to Polycystic Kidney, Autosomal Dominant

Share to Repetitive Sequences, Amino Acid

Share to TRPP Cation Channels

Source

Identifiers

PMID: 10322638
DOI: 10.1002/(SICI)1520-6408(1999)24:3/4<299::AID-DVG13>3.0.CO;2-J

Genes

PKD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Peptides from the PKD repeats of polycystin, the PKD1 gene product, modulate pattern formation in the developing kidney.PMID 10322638Read ↗

The polycystin-1 C-terminal fragment triggers branching morphogenesis and migration of tubular kidney epithelial cells.Semantic proximity Read ↗

Leucine-rich repeat in polycystin-1 suppresses cystogenesis in a zebrafish (Danio rerio) model of autosomal dominant polycystic kidney diseaseSemantic proximity Read ↗

Comparison of Pkd1-targeted mutants reveals that loss of polycystin-1 causes cystogenesis and bone defects.Semantic proximity Read ↗

Defining a link with autosomal-dominant polycystic kidney disease in mice with congenitally low expression of Pkd1.Semantic proximity Read ↗

Pioglitazone improves the phenotype and molecular defects of a targeted Pkd1 mutant.Semantic proximity Read ↗

Polycystin-1 binds Par3/aPKC and controls convergent extension during renal tubular morphogenesisSemantic proximity Read ↗

Tubular obstruction induced polycystin upregulation is pro-fibrotic and induced a severe cystic phenotype in adult mice with autosomal dominant polycystic kidney disease: the coexistence of polycystin loss and gain function in ADPKDSemantic proximity Read ↗

Structure–function relationships of the extracellular domain of the autosomal dominant polycystic kidney disease‐associated protein, polycystin‐1Semantic proximity Read ↗

Polycystin-1, the gene product of PKD1, induces resistance to apoptosis and spontaneous tubulogenesis in MDCK cells.Semantic proximity Read ↗

Kidney-specific inactivation of the Pkd1 gene induces rapid cyst formation in developing kidneys and a slow onset of disease in adult miceSemantic proximity Read ↗

Identification of a new target molecule for a cascade therapy of polycystic kidney.Semantic proximity Read ↗

Essential role of cleavage of Polycystin-1 at G protein-coupled receptor proteolytic site for kidney tubular structure.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.