Article

Cytotoxic CD4 <sup>+</sup> T cells in the bone marrow compromise healthy ageing by enhancing granulopoiesis

2024-01-29

Abstract excerpt

Neutrophils are the most abundant leukocytes in the blood, with numbers further increasing with age. Despite their essential role as a primary line of defense, neutrophils can contribute to tissue damage and age-related diseases 1 and a high neutrophil-to-lymphocyte ratio predicts all causes of mortality in the elderly 2–5 . However, the precise mechanisms driving enhanced neutrophil generation during ageing rem...

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Literature Corpus work: a00fb989-cba1-559b-bfd5-258922973ac1
DOI: 10.1101/2024.01.26.577360

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