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Article

Circulating TNF and mitochondrial DNA are major determinants of neutrophil phenotype in the advanced-age, frail elderly.

Molecular immunology - 1 May 2015

Verschoor Chris P, Loukov Dessi, Naidoo Avee, Puchta Alicja, Johnstone Jennie, Millar Jamie, Lelic Alina, Novakowski Kyle E, Dorrington Michael G, Loeb Mark, Bramson Jonathan L, Bowdish Dawn M E

Abstract excerpt

Tumor necrosis factor (TNF), a potent inflammatory cytokine, and mitochondrial DNA (mtDNA), a product of inflammation-induced tissue damage, increase with age ("inflammaging") and many chronic diseases. Peripheral blood neutrophils, a critical component of innate immunity, have also been shown to...

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Identifiers

PMID: 25660689
DOI: 10.1016/j.molimm.2015.01.015

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25660689-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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