Article
Circulating TNF and mitochondrial DNA are major determinants of neutrophil phenotype in the advanced-age, frail elderly.
Molecular immunology - 1 May 2015
Verschoor Chris P, Loukov Dessi, Naidoo Avee, Puchta Alicja, Johnstone Jennie, Millar Jamie, Lelic Alina, Novakowski Kyle E, Dorrington Michael G, Loeb Mark, Bramson Jonathan L, Bowdish Dawn M E
Abstract excerpt
Tumor necrosis factor (TNF), a potent inflammatory cytokine, and mitochondrial DNA (mtDNA), a product of inflammation-induced tissue damage, increase with age ("inflammaging") and many chronic diseases. Peripheral blood neutrophils, a critical component of innate immunity, have also been shown to be altered with age, and are exceptionally sensitive to external stimuli. Herein, we describe that the phenotype of...
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