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Article

CXCR4, the master regulator of neutrophil trafficking in homeostasis and disease.

European journal of clinical investigation - 1 Nov 2018

De Filippo Katia, Rankin Sara M

Abstract excerpt

BACKGROUND: Chemokines play a critical role in orchestrating the distribution and trafficking of neutrophils in homeostasis and disease. RESULTS: The CXCR4/CXCL12 chemokine axis has been identified as a central regulator of these processes. CONCLUSION: In this review, we focus on the role of CXCR4/CXCL12 chemokine axis in regulating neutrophil release from the bone marrow and the trafficking of senescent...

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Identifiers

PMID: 29734477
DOI: 10.1111/eci.12949
PMCID: PMC6767022

Genes

CXCR4
CXCL12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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