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Genetic and transcriptomic characteristics of RhlR-dependent quorum sensing in cystic fibrosis isolates of <i>Pseudomonas aeruginosa</i>

2021-12-22

Abstract excerpt

In people with the genetic disease cystic fibrosis (CF), bacterial infections involving the opportunistic pathogen Pseudomonas aeruginosa are a significant cause of morbidity and mortality. P. aeruginosa uses a cell-cell signaling mechanism called quorum sensing (QS) to regulate many virulence functions. One type of QS consists of acyl-homoserine lactone (AHL) signals produced by LuxI-type signal synthases, whic...

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Literature Corpus work
8b6f0c1c-582a-5424-ab4b-cf1bf2638675
DOI
10.1101/2021.12.21.470774
Open publication

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