Article
Pseudomonas aeruginosa lasR mutants resist phagocytosis and alter inflammatory cytokine production by cystic fibrosis macrophages.
mSphere - 28 Apr 2026
Aridgides Daniel S, Mellinger Diane L, Gwilt Lorraine L, Correia Anthony R, Finger Carson E, Goddard Jay, Hampton Thomas H, Mould Dallas L, Hogan Deborah A, Ashare Alix
Abstract excerpt
Cystic fibrosis (CF) is characterized by chronic muco-obstructive lung disease and infection. People with CF (pwCF) are often colonized with Pseudomonas aeruginosa for years to decades, allowing for evolutionary adaptation. In chronic P. aeruginosa lung isolates from pwCF, the quorum-sensing regulator LasR is frequently nonfunctional; however, the factors enabling lasR loss-of-function (LOF) mutant selection are...
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