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Mutation of Pseudomonas aeruginosa lasI/rhlI diminishes its cytotoxicity, oxidative stress, inflammation, and apoptosis on THP-1 macrophages.

Microbiology spectrum - 3 Oct 2024

Ren Yanying, You Xiaojuan, Zhu Rui, Li Dengzhou, Wang Chunxia, He Zhiqiang, Hu Yue, Li Yifan, Liu Xinwei, Li Yongwei

Abstract excerpt

The management of Pseudomonas aeruginosa (P. aeruginosa) infections presents a substantial challenge to clinics and public health, emphasizing the urgent need for innovative strategies to address this issue. Quorum sensing (QS) is an intercellular communication mechanism that coordinates bacterial activities involved in various virulence mechanisms, such as acquiring host nutrients, facilitating biofilm...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39162513
DOI: 10.1128/spectrum.04146-23
PMCID: PMC11448257

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