Article
Growth phenotypes of Pseudomonas aeruginosa lasR mutants adapted to the airways of cystic fibrosis patients.
Molecular microbiology - 1 Apr 2007
D'Argenio David A, Wu Manhong, Hoffman Lucas R, Kulasekara Hemantha D, Déziel Eric, Smith Eric E, Nguyen Hai, Ernst Robert K, Larson Freeman Theodore J, Spencer David H, Brittnacher Mitchell, Hayden Hillary S, Selgrade Sara, Klausen Mikkel, Goodlett David R, Burns Jane L, Ramsey Bonnie W, Miller Samuel I
Abstract excerpt
The opportunistic pathogen Pseudomonas aeruginosa undergoes genetic change during chronic airway infection of cystic fibrosis (CF) patients. One common change is a mutation inactivating lasR, which encodes a transcriptional regulator that responds to a homoserine lactone signal to activate expression of acute virulence factors. Colonies of lasR mutants visibly accumulated the iridescent intercellular signal...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.