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Quorum-sensing synthase mutations re-calibrate autoinducer concentrations in clinical isolates of Pseudomonas aeruginosa to enhance pathogenesis

2023-06-29

Abstract excerpt

Quorum sensing is a mechanism of bacterial communication that controls virulence gene expression. Pseudomonas aeruginosa regulates virulence via two synthase/transcription factor receptor pairs: LasI/R and RhlI/R. LasR is considered the master transcriptional regulator of quorum sensing, as it upregulates rhlI/R . However, clinical isolates often have frequent inactivating mutations in lasR , while maintaining Rhl...

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Literature Corpus work
c3562eba-8e80-52b3-8d15-d2978f1835a4
DOI
10.21203/rs.3.rs-3068935/v1
Open publication

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Quorum-sensing synthase mutations re-calibrate autoinducer concentrations in clinical isolates of Pseudomonas aeruginosa to enhance pathogenesisDOI 10.21203/rs.3.rs-3068935/v1
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