Pseudomonas aeruginosa lasR-deficient mutant contributes to bacterial virulence through enhancing the PhoB-mediated pathway in response to host environment.

Abstract excerpt

Pseudomonas aeruginosa is a major opportunistic pathogen that causes lung infections in patients with cystic fibrosis and chronic obstructive pulmonary disease. Loss-of-function mutations in the quorum-sensing regulatory gene lasR commonly arise during chronic infections, which are associated with exaggerated inflammation and accelerated decline in lung function. Here, in a murine cutaneous abscess model,...

Topics

• Pseudomonas aeruginosa
• Bacterial Proteins
• Animals
• Trans-Activators
• Mice
• Virulence
• Pseudomonas Infections
• Gene Expression Regulation, Bacterial
• Quorum Sensing
• Disease Models, Animal