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Correcting differential gene expression analysis for cyto-architectural alterations in substantia nigra of Parkinson’s disease patients reveals known and potential novel disease-associated genes and pathways

2021-05-26

Abstract excerpt

Several studies have analyzed gene expression profiles in the substantia nigra to better understand the pathological mechanisms causing Parkinson’s disease (PD). However, the concordance between the identified gene signatures in these individual studies was generally low. This might be caused by a change in cell type composition as loss of dopaminergic neurons in the substantia nigra pars compacta is a hallmark of...

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Literature Corpus work
9ffc294d-c232-567b-bc67-a5d9c5856c1d
DOI
10.1101/2021.05.25.445590
Open publication

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Correcting differential gene expression analysis for cyto-architectural alterations in substantia nigra of Parkinson’s disease patients reveals known and potential novel disease-associated genes and pathwaysDOI 10.1101/2021.05.25.445590
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