Article

Distinct spatial transcriptomic patterns of substantia nigra in Parkinson disease and Parkinsonian subtype of multiple system atrophy

2025-04-02

Abstract excerpt

<title>Abstract</title> <p>To investigate transcriptomic signatures of Parkinson's disease (PD) and the Parkinsonian subtype of Multiple System Atrophy (MSA-P) in the substantia nigra pars compacta (SNpc), we conducted transcriptome analysis using in-situ hybridization on paraffin-embedded SNpc tissues from postmortem brains. The study included 2 MSA-P patients, 2 PD patients, and 2 healthy controls (HC), with 12...

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Literature Corpus work: dc46fb47-2c11-58b5-8637-59c0d3878b9a
DOI: 10.21203/rs.3.rs-6225459/v1

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