Article

Common gene expression signatures in Parkinson’s disease are driven by changes in cell composition

2019-09-24

Abstract excerpt

<h4>Background</h4> The etiology of Parkinson’s disease (PD) is largely unknown. Genome-wide transcriptomic studies in bulk brain tissue have identified several molecular signatures associated with the disease. While these studies have the potential to shed light into the pathogenesis of PD, they are also limited by two major confounders: RNA post mortem degradation and heterogeneous cell type composition of bulk...

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Literature Corpus work: 9c204ede-43cc-5dc1-9341-c47551c5b4eb
DOI: 10.1101/778910

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