Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TERT promoter mutations in primary liver tumors.

Clinics and research in hepatology and gastroenterology - 1 Feb 2016

Nault Jean-Charles, Zucman-Rossi Jessica

Abstract excerpt

Next-generation sequencing has drawn the genetic landscape of hepatocellular carcinoma and several signaling pathways are altered at the DNA level in tumors: Wnt/β-catenin, cell cycle regulator, epigenetic modifier, histone methyltransferase, oxidative stress, ras/raf/map kinase and akt/mtor pathways. Hepatocarcinogenesis is a multistep process starting with the exposure to different risk factors, followed by the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Telomerase
Share to Promoter Regions, Genetic
Share to Adenoma, Liver Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Hepatocellular

Share to CTNNB1 gene

Share to TERT gene

Share to Liver Neoplasms

Share to Mutation

Source

Identifiers

PMID: 26336998
DOI: 10.1016/j.clinre.2015.07.006

Genes

TERT
CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TERT promoter mutations in primary liver tumors.PMID 26336998Read ↗

Frequency and geographic distribution of TERT promoter mutations in primary hepatocellular carcinomaSemantic proximity Read ↗

Frequent somatic TERT promoter mutations and CTNNB1 mutations in hepatocellular carcinoma.Semantic proximity Read ↗

Telomerase reverse transcriptase mutations in plasma DNA in patients with hepatocellular carcinoma or cirrhosis: Prevalence and risk factorsSemantic proximity Read ↗

Geographic and Viral Etiology Patterns of TERT Promoter and CTNNB1 Exon 3 Mutations in Hepatocellular Carcinoma: A Comprehensive ReviewSemantic proximity Read ↗

Significance of TERT Genetic Alterations and Telomere Length in Hepatocellular CarcinomaSemantic proximity Read ↗

TERT Promoter Mutations Combined with TP53 Mutations as Potential Biomarkers for Hepatocellular Carcinoma Recurrence and PrognosisSemantic proximity Read ↗

TERT promoter mutation in resectable hepatocellular carcinomas: a strong association with hepatitis C infection and absence of hepatitis B infection.Semantic proximity Read ↗

Tumor specific mutations in TERT promoter and CTNNB1 gene in hepatitis B and hepatitis C related hepatocellular carcinoma.Semantic proximity Read ↗

Frequency of somatic mutations in TERT promoter, TP53 and CTNNB1 genes in patients with hepatocellular carcinoma from Southern ItalySemantic proximity Read ↗

The TERT promoter mutation incidence is modified by germline TERT rs2736098 and rs2736100 polymorphisms in hepatocellular carcinoma.Semantic proximity Read ↗

Frequency of TERT promoter mutations in primary tumors of the liver.Semantic proximity Read ↗

Reactivation of telomerase reverse transcriptase expression in cancer: the role of TERT promoter mutationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.