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Article

Erythromyeloid-Derived TREM2: A Major Determinant of Alzheimer's Disease Pathology in Down Syndrome.

Journal of Alzheimer's disease : JAD - 1 Jan 2018

Raha-Chowdhury Ruma, Henderson James W, Raha Animesh Alexander, Stott Simon R W, Vuono Romina, Foscarin Simona, Wilson Liam, Annus Tiina, Fincham Robert, Allinson Kieren, Devalia Vinod, Friedland Robert P, Holland Anthony, Zaman Shahid H

Abstract excerpt

BACKGROUND: Down syndrome (DS; trisomy 21) individuals have a spectrum of hematopoietic and neuronal dysfunctions and by the time they reach the age of 40 years, almost all develop Alzheimer's disease (AD) neuropathology which includes senile plaques and neurofibrillary tangles. Inflammation and innate immunity are key players in AD and DS. Triggering receptor expressed in myeloid cells-2 (TREM2) variants have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29278889
DOI: 10.3233/JAD-170814
PMCID: PMC5817909

Genes

TREM2

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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