Article
Down syndrome individuals with Alzheimer's disease have a distinct neuroinflammatory phenotype compared to sporadic Alzheimer's disease.
Neurobiology of aging - 1 Sept 2015
Wilcock Donna M, Hurban Jennifer, Helman Alex M, Sudduth Tiffany L, McCarty Katie L, Beckett Tina L, Ferrell Joshua C, Murphy M Paul, Abner Erin L, Schmitt Frederick A, Head Elizabeth
Abstract excerpt
Down syndrome (DS) is the most common genetic cause of intellectual disability and is primarily caused by the triplication of chromosome 21. The overexpression of amyloid precursor protein gene may be sufficient to drive Alzheimer's disease (AD) neuropathology that is observed in virtually all individuals with DS by the age of 40 years. There is relatively little information about inflammation in the DS brain and...
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