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Article

The H2A.Z histone variant integrates Wnt signaling in intestinal epithelial homeostasis

23 Apr 2019

Abstract excerpt

The Tip60/p400 chromatin-modifying complex, which is involved in the incorporation and post-translational modification of the H2A.Z histone variant, regulates cell proliferation and important signaling pathways, such as Wnt. Here, we study the involvement of H2A.Z in intestinal epithelial homeostasis, which is dependent on the finely-tuned equilibrium between stem cells renewal and differentiation, under the...

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PMID: 31015444
DOI: 10.1038/s41467-019-09899-z

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